Clinical Study 1

Maeda, T., Yamamoto, T., Isikawa, Y., Itoh, N. & Arase, S. Sanguisorba Officinalis Root Extract Has FGF-5 Inhibitory Activity and Reduces Hair Loss by Causing Prolongation of the Anagen Period. Nishinihon J. Dermatology 69, 81–86 (2007). Original article in Japanese Using engineered cell lines in vitro Advangen’s scientists identified FGF5 inhibitory activity in several botanical extracts including Rosa multiflora and Sanguisorba officinalis. A topical solution of S. officinalis extract was tested in a double blind, randomised, placebo controlled trial of 39 individuals (males and females) suffering hair loss. After 4 months of use, participants in the topical S. officinalis treatment group had a significant reduction in shed hair (p<0.01) with a concurrent reduction in shed vellus hair (p<0.01). Hair growth rate was assessed by phototrichograms and was shown to be increased by 18% (p<0.01). The proportion of anagen follicles in treated individuals was increased by 10% (p<0.01). User surveys highlighted performance satisfaction, with >75% of the treatment group labelling the solution as at least somewhat effective vs. only 25% of the placebo group.